Coverage will span Channel 4, digital channel More4 and the Channel 4 website.
The multi-platform coverage is being billed the biggest broadcasting event in Channel 4’s 30-year history and “the most extensive UK coverage that has ever been dedicated to the Paralympic Games.”
Veteran news presenter Jon Snow will lead coverage of the closing and opening ceremonies and Clare Balding and former Paralympic wheelchair basketball medallist Ade Adepitan will head the peak time Games coverage.
The broadcaster says 50% of its presenters and reporters will be disabled, including former Paralympic middle-distance runner Danny Crates and former Paralympic swimmer Giles Long.
Jay Hunt, Chief Creative Officer at Channel 4, said: “Being the broadcaster of the London 2012 Paralympic Games is a huge privilege and an opportunity for us to really make a difference to the perception of disability and disability sport in this country.
“I’m thrilled to announce this brilliant and carefully selected team of presenters and reporters; a mix of broadcasting heavyweights and new faces including disabled talent.
“Our coverage will contain in-depth analysis and intelligent, frank and thought-provoking insight from people who are equipped to bring these incredible but little-understood sports to a broad mainstream audience and help us to make this the biggest Paralympic Games ever.”